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The inflammation in RA causes a shift in the bone metabolism towards increased osteoclast-mediated bone turn-over .
The objective of this study was to examine if serological markers widely used in daily clinical practice also can predict early involvement of bone measured by DXR in a longitudinal study of patients with RA of short disease duration.
The patients with and without hand X-rays had similar baseline characteristics (Table ).
Treatment was given according to clinical practice.
The precision of the DXR-BMD measurements was calculated based on duplicate hand radiographs from 28 healthy individuals with repositioning of the hand between each measure.Radiographic progression in rheumatoid arthritis (RA) has in several studies been shown to be predicted by serological markers widely used in daily clinical practice.The objective of this longitudinal study was to examine if these serological markers also predict hand bone mineral density (BMD) loss in patients with RA of short disease duration.The values are given as median (inter quartile range) for continuous variables, percentage for counts.